With the support of our advanced protein engineering platform established for many years, Creative BioMart has successfully designed a variety of therapeutic proteins with novel topologies and functional activities based on computational design. Our scientists provide you with a comprehensive customized therapeutic protein folding recognition service to identify protein folding, misfolding, and refolding of therapeutic proteins, providing new therapeutic strategies for treating protein misfolding diseases.

Protein folding is the process by which a polypeptide chain acquires its functional, native 3D structure. However, protein misfolding prevents the protein from folding into its native functional conformation. Many factors have been reported to be involved in protein folding. Somatic or genetic mutations such as loss of organelle DNA, high temperature, acidic or basic pH, high sugar or oxidative stress, metal ions, aging can lead to misfolding. Misfolded proteins have two main fates. One is that the misfolded protein is degraded (cleared) from the system, resulting in the loss of the function provided by the protein. The second is the aggregation of misfolded proteins, leading to the gain of toxic function, the precipitation of many serious diseases, such as cystic fibrosis (CF), Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic side solenoid sclerosis (ALS), etc. Therefore, scientists are working on potential treatments aimed at minimizing protein misfolding.

Fig 1. Protein misfolding and degradation pathways. (Yadav K, et al., 2019 )

Services

The purpose of drug design and protein de novo design is to use the rules of protein folding to create proteins with new functions, and significant progress has been made in the development of drugs and medical diagnostics. Creative BioMart is an expert in identifying therapeutic protein misfolding and is working to develop potential treatments that reduce protein misfolding. We provide the following methods that work directly by mitigating protein misfolding:

• Biologics (antibody or peptide).
• Folding correctors (including pharmacological partners).
• Regulation of the protein homeostasis network.

In addition, we are committed to research to develop treatments for protein misfolding diseases. The development of therapeutic strategies for these diseases has yielded remarkable results. Three promising approaches include:

(1) Inhibition of protein aggregation by peptides or small molecules identified by structure-based drug design or high-throughput screening.

(2) Interfere with post-translational modifications that stimulate protein misfolding and aggregation

(3) Up-regulation of molecular chaperones or aggregate clearance mechanisms.

Service Principle

Creative BioMart is based on innovative, pragmatic and honest, adhering to the tenet of "Quality is our life, providing customers with the best quality service", providing customized services to customers around the world.

We will be glad to discuss details of intended interaction studies with you and develop experimental strategies/methods tailored to your requirement. Our customer service representatives are enthusiastic and trustworthy 24 hours a day, Monday to Friday. If you are interested in our services, please do not hesitate to contact us for more information or to discuss in detail.

References

1. Yadav K, Yadav A, Vashistha P, et al.. (2019) Protein misfolding diseases and therapeutic approaches[J]. Current Protein and Peptide Science. 20(12): 1226-1245.
2. Shin H C. (2001) Protein folding, misfolding, and refolding of therapeutic proteins[J]. Biotechnology and Bioprocess Engineering. 6(4): 237-243.

• B Cell Epitope Prediction Service
• Ion Channel Modeling Service
• Molecular Dynamics Simulation of RNA Systems
• T Cell Epitope Prediction Service
• Therapeutic Protein Functional Motion Analysis Service
• Therapeutic Protein Species Assessment Service