Creative BioMart is a well-known expert who is committed to developing a variety of protein biomaterials as multifunctional platforms to study and solve various challenges in regenerative medicine. With years of experience, we provide customized services for silk-based materials (natural and reconstituted) that have been fabricated into a variety of material forms including films, sponges, scaffolds, fibers, tubes and nano/micro particles for specific use applications.

Introduction of Silk Biomaterials

Silk is a class of proteinaceous material produced by arthropods for various purposes. Among them, spider silk and silk silk are known for their excellent mechanical properties, high biocompatibility, good biodegradability, and lack of immunogenicity and allergy. Driven by rational design and ingenuity, scientists can engineer innovative recombinant silk proteins with diverse functions to address biomedical and technological challenges. As a promising biomaterial, silk has moved beyond traditional textile applications into tissue engineering, drug delivery, and biodegradable medical devices.

Fig 1. Engineering of silk proteins for materials applications. (Saric M, et al., 2019)

Services

Currently, researchers in different disciplines are studying the application of functionalized recombinant silk proteins as green biopolymers. Functionalization of silk proteins enables the development of a variety of materials with unprecedented versatility. As a leading service provider of protein engineering, Creative BioMart is developing a broad portfolio of biomaterials based on our proprietary silk protein platform. Our scientists are committed to developing multiple strategies to gain insight into the structure-function relationship of silk materials. We provide one-stop service for silk protein:

• Multimodal characterization: we employ a variety of silk protein techniques including X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR)/Raman Spectroscopy, Transmission Electron Microscopy (TEM), Nuclear Magnetic Resonance Spectroscopy and Scanning Infrared Near Field Optics Microscopy (IR-SNOM) for nanoscale characterization of silk conformation
• Multilevel modification: we provide multi-level modification services for silk biomaterials by means of direct feeding, genetic modification, chemical binding, mesoscopic assembly and macroscopic mixing. We will choose the right method for your project, providing new opportunities to realize new functions of silk biomaterials or silk-based devices, such as reinforced silk fibers, photosensitive silk photoresists, silk screws with drug release function, etc.
• Multiscale manufacturing: we provide multiscale manufacturing services for silk biomaterials, including electron beam lithography, ion beam lithography, soft lithography, nanoimprint lithography, scanning probe lithography, multiphoton lithography, etc. Aims to create novel biological structures as functional devices and interfaces.

Creative BioMart is committed to developing silk-based materials utilizing silk's excellent mechanical strength, cytocompatibility, biodegradability, optical transparency of thin films, and easy addition of functional doping, providing useful materials for applications in optics, transient devices, pharmaceuticals delivery and tissue engineering. We will work with you to develop the most appropriate strategy and provide the most meaningful data for your research for accelerating the research of life sciences. If you are interested in our services, please do not hesitate to contact us for more information.

References

1. Zhou Z, Zhang S, Cao Y, et al.. (2018) Engineering the future of silk materials through advanced manufacturing. Advanced Materials. 30 (33): 1706983.
2. Saric M, Scheibel T. (2019) Engineering of silk proteins for materials applications. Current opinion in biotechnology. 60: 213-220.

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