Creative BioMart is a well-known expert who is committed to developing a variety of protein therapies to improve the effectiveness and safety of protein therapy, and to allow the production of new types of proteins and effects. With years of experience, we provide customized services for protein hormones as protein therapeutics to precisely meet customer requirements.

Introduction of Therapeutic Protein Hormones

Certain diseases characterized by a deficiency or complete loss of endogenous proteins can be treated with alternative therapies that closely mimic the natural pathways of many physiological functions. The most widely recognized protein therapeutics in this field are protein hormones or peptide hormones, including insulin and human growth hormone. More than 60 peptide drugs are currently approved in the US and other major markets. Insulin as a macromolecule has played a prominent role in medical practice since the 1920s. The in vivo formulation, route of administration, rate, and pharmacokinetic characteristics of peptide drugs are critical to the success of protein drug delivery. Peptide drug discovery has diversified from traditional endogenous human peptide discovery to include broader structures determined from other natural sources or through medicinal chemistry efforts.

Fig 1. The evolution of peptide therapeutics. (Lau J L, et al., 2018)

Services

Peptide therapy is limited by the short plasma half-life and low oral bioavailability of native peptides. In addition, the large ligand-binding sites of some peptide GPCRs and the specific conformational changes required for signal transduction pose significant challenges for small-molecule drug discovery. As a leading service provider of protein engineering, Creative BioMart has established a powerful protein hormone-based protein therapeutics platform, providing peptide drug discovery, peptide drug synthesis and peptide screening services.

Our scientists are working on all aspects of developing protein hormone therapy therapies to realize the potential utility of peptide drugs in a wide range of indications. Our main strategies include:

• Peptide lengths: we utilize improved peptide synthesis and manufacturing techniques and widely popular molecular targets to develop peptide drugs that are uniformly distributed over a length range of up to 40 amino acids.
• Natural peptide improvement: we use modification of natural peptides, analogs and heterologous peptides produced by synthetic or recombinant expression to improve drug properties.
• Peptide properties: we use conjugation to alter or enhance the properties of peptide and protein drug candidates. Extend the half-life of peptide drugs by conjugation to polyethylene glycol (PEG), lipids and proteins such as Fc fragments.

These strategies we provide allow for modulation of pharmacokinetic properties and target specificity through amino acid or backbone modifications, incorporation of unnatural amino acids, and extension of half-life or improved solubility. Creative BioMart is committed to designing customized therapeutic peptide hormones or protein hormones for global biopharmaceutical companies. We will work with you to develop the most appropriate strategy and provide the most meaningful data for your research for accelerating the research of life sciences. If you are interested in our services, please do not hesitate to contact us for more information.

Reference

1. Lau J L, Dunn M K. (2018) Therapeutic peptides: Historical perspectives, current development trends, and future directions. Bioorganic & medicinal chemistry. 26(10): 2700-2707.

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