Wound-healing materials are protein-based biomaterials designed through rational design strategies and have important applications in biomedicine. With its advanced protein engineering platform established over the years, Creative BioMart is developing several wound dressings with specific properties to meet the healing requirements of different types of wounds. Our scientists are committed to providing fully customized biomaterials for wound healing solutions to customers around the world.

Introduction of Wound Healing Biomaterials

The skin plays a key role in protecting our internal environment from the external environment, maintaining homeostasis and regulating temperature. Current wound dressings, dressings containing growth factors to stimulate and facilitate the wound healing process, and skin substitutes containing patient-derived cells are used to treat wounds and burns. The most widely used of these are wound dressings. In recent years, as materials and technologies have developed, materials for wound healing treatments can be produced more economically. For example, the ability to manufacture scaffolds using 3D printing technology enables the development of skin substitutes, as well as the ability to print scaffolds directly onto certain parts of the body. Protein-based biomaterials offer a unique and powerful approach as these molecules participate in biomechanical reactions and control the structure and function of macromolecules. The structural flexibility and biocompatibility of proteins make them ideal materials for wound healing biomaterial engineering.

Fig 1. Schematic representation of a wound dressing, designed to create a sealed wound environment to keep out pathogens and promote the wound healing process. (Murray R Z, et al., 2009)

Solutions

While existing dressings and skin substitutes for wound healing are good, they can be improved. Creative BioMart has successfully utilized rationally designed protein engineering strategies to develop a variety of protein-based wound-healing materials with specific properties to meet the healing requirements of different types of wounds. In order to provide customized high-quality wound healing materials to global customers, we rationally design the following proteins to provide solutions for wound healing, including but not limited to:

• Collagen based wound healing biomaterials
  Our protein engineers improve collagen performance through protein engineering techniques. The collagen-based wound dressings we designed have the ability to absorb wound exudate and maintain a moist wound environment, and are particularly suitable for addressing elevated levels of MMPs in chronic wounds.
• Silk fibroin based wound healing biomaterials
  Our protein engineers use various forms of silk fibroin, including solutions, films, silk fibroin nanofiber mats, hydrogels, hydrocolloid dressings, and sponges, as potential biomaterials to promote wound healing. In addition, we add anti-inflammatory agents, antiseptics, antibiotics, nanoparticles and other bioactive agents to silk fibroin to promote wound healing.
• Elastin based wound healing biomaterials
  Our protein engineers design and synthesize new materials based on elastin or elastin-like peptides for burn wound treatment.
• Keratin based wound healing biomaterials
  Our protein engineers use various forms of keratin, including films, sponges, fibers, hydrogels and porous scaffolds, to promote wound healing and improve quality of life.

Advantages of Protein-based Wound Healing Biomaterials

Protein-based wound healing biomaterials have several advantages over other synthetic or natural polymers for biomedical applications.

• Thermally and environmentally stable up to about 200 °C.
• Showing higher activity.
• Inducing higher wound repair gene expression and higher cell motility.
• With binding sites for cell adhesion, no further modifications are required for cell adhesion and proliferation.
• Creating an environment that closely resembles natural skin, mimicking materials present in the dermis in terms of structure and biological function.

Creative BioMart has in-depth knowledge and experience of the tools and processes involved in biomaterials development, and provides professional protein-based wound-healing materials production solutions for the customers. Whether your wound-healing materials are in the discovery stages, or are planning engineered wound-healing materials production, please contact us to discuss further details to ensure your next success.

Reference

1. Murray R Z, West Z E, Cowin A J, et al.. (2019) Development and use of biomaterials as wound healing therapies[J]. Burns & trauma. 7.

• Biomaterials for Adhesives
• Biomaterials for Tissue Regeneration