The drug delivery of therapeutic macromolecules such as proteins and nucleic acids has always been a great challenge. Scientists have successfully used nanoparticles as drug delivery systems for small and large therapeutic molecule carriers for cancer treatment. Supported by advanced protein engineering platforms established over the years, Creative BioMart has developed protein nano-multifunctional drug delivery systems to enhance drug bioavailability in vivo and enhance therapeutic efficacy. Our scientists are committed to providing fully customized drug targeted delivery solutions to customers around the world.

Introduction of Protein Nanoparticles Drug Delivery

Many proteins and peptides, such as insulin, vaccines, antibodies, and various recombinant proteins have been used in medicine and therapy, and one of the important research areas in nanomedicine is the development of new drug delivery systems to improve their functions and properties. Protein nanoparticles have been extensively studied as multifunctional drug delivery systems due to their abundance in natural sources, biocompatibility, biodegradability, facile synthetic processes, and cost-effectiveness. Furthermore, protein-based nanoparticles offer the opportunity for surface modification by conjugating other proteins and carbohydrate ligands. The development of protein engineering technology provides a powerful tool for the functionalization of protein nanoparticles, which can improve the therapeutic efficacy and safety of anticancer drugs.

Fig 1. Conceptual design and fabrication pipeline of nanostructured drug delivery systems. (Vazquez E, et al., 2016)

Solutions

Compared to other particle systems, protein nanoparticles do not have limitations such as potential toxicity, large size, accumulation or rapid clearance from the body. It has thus been increasingly used for a variety of applications, most notably for the delivery of therapeutic and diagnostic agents. Creative BioMart has built nanotherapeutics platforms with the potential to revolutionize the field of drug delivery. Here, we modify three interfaces of protein nanoparticles, including internal, external, and inter-subunit interfaces. We can help you achieve a drug entity in the body that is protected in the systemic circulation, restricting drug entry to selected sites, and delivering the drug to the site of action at a controlled and sustained rate.

Our scientists have successfully used proteins from various sources (such as silk proteins, albumin, protamines, gliadin, legumin, collagen, gelatin and recombinant proteins) to prepare nanoparticles through a simple, economical and environmentally friendly synthesis process, and developed a variety of different new drug carrier systems in the micro and nano size range. We employ the following methods to prepare protein nanoparticles:

• Salt precipitation (salting out).
• Emulsion solvent extraction.
• Agglomeration or desolvation.
• Polyelectrolyte complexation.
• Electrospray.

Applications of Protein Nanoparticles

• Our proven protein engineering technology platform opens up new avenues for protein nanoparticles in drug delivery, which are widely used to deliver various therapeutic molecules such as nucleic acids, growth factors, vaccines and therapeutics.
• Our designed protein nanoparticles can also control and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules.

Creative BioMart has in-depth knowledge and experience of the tools and processes involved in protein nanoparticles development, and provides professional drug targeted delivery solutions based protein nanoparticles. Whether your protein nanoparticles are in the discovery and screening stages, or are planning protein nanoparticles production, please contact us to discuss further details to ensure your next success.

References

1. Vazquez E, Mangues R, Villaverde A. (2016) Functional recruitment for drug delivery through protein-based nanotechnologies. Nanomedicine (Lond). 11(11):1333-6.
2. Jahanshahi M, Babaei Z. (2008) Protein nanoparticle: a unique system as drug delivery vehicles[J]. African journal of Biotechnology. 7(25).

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