With the support of our advanced protein engineering platform established for many years, Creative BioMart has developed a variety of theoretical prediction methods for protein structure. Our scientists provide you with a comprehensive customized protein structure modeling service.

Proteins are linear polymers that can fold into an incredible variety of three-dimensional structures that provide complex functions for biology. Therefore, obtaining the structure of a protein is critical both for understanding the basic biology of health and disease, and for developing therapeutic molecules. Protein structures have traditionally been determined by experimental methods (X-ray crystallography and nuclear magnetic resonance), but they require trained personnel, expensive equipment, lengthy analyses and relatively large amounts of proteins. Computational structure predictions from genetically encoded amino acid sequences of proteins have now been used as an alternative. Scientists use computational modeling to predict the three-dimensional structure of proteins from the genome, predict the properties or behavior of proteins, and even modify or design new proteins to obtain desired functions.

Fig 1. Schematic representation of several architectures used in protein modeling and design. (Gao W, et al., 2020 )

Services

Improvements in computational techniques over the past few decades have led to significant progress in protein structure prediction methods, with template-based methods having the highest accuracy. Creative BioMart has tried and developed many methods and computational algorithms for protein structure modeling to predict the three-dimensional (3D) structure of proteins, such as comparative modeling, ab initio modeling, Rosetta, MODELLER, SWISS-model, etc. We offer a wide range of advanced structural modeling services for protein sequences:

• Homology Modeling Service
• Fold Recognition Service
• De Novo Prediction Service

Facts have proved that our protein structure modeling service provides a reliable basis for designing new proteins or modifying existing proteins, and at the same time provides reasonable target molecules and structures for the design of new drug molecules. Our team of experts can accurately model the appropriate method system of your choice, so you don't have to worry about technical issues.  Determining the structure of a protein experimentally is very difficult. While experimental structures are always better than models, you may need our services when:

• A protein may belong to a notoriously difficult class.
• You need specific expertise and equipment to solve protein structures.
• Even with this expertise and equipment, structural solutions projects can fail.

Service Principle

Creative BioMart is based on innovative, pragmatic and honest, adhering to the tenet of "Quality is our life, providing customers with the best quality service", providing customized services to customers around the world.

We will be glad to discuss details of intended interaction studies with you and develop experimental strategies/methods tailored to your requirement. Our customer service representatives are enthusiastic and trustworthy 24 hours a day, Monday to Friday. If you are interested in our services, please do not hesitate to contact us for more information or to discuss in detail.

References

1. Gao W, Mahajan S P, Sulam J, et al.. (2020) Deep learning in protein structural modeling and design[J]. Patterns. 100142.
2. Fiser A. (2004) Protein structure modeling in the proteomics era[J]. Expert review of proteomics. 1(1): 97-110.

• Protein Structure Assessment Service