Creative BioMart is a well-known expert who is committed to developing a variety of protein biomaterials as multifunctional platforms to study and solve various challenges in regenerative medicine. With years of experience, we provide customized services for coiled-coil-based materials have been fabricated into a variety of material forms including hydrogels, nanotubes, nanosheets, and even composites of synthetic polymers or inorganic nanoparticles.

Introduction of Coiled-coil Biomaterials

A coiled-coil is a supercoiled protein structural motif consisting of two or more α-helical peptides intertwined in a supercoiled fashion. Coiled-coils, one of the most ubiquitous folding motifs in proteins, are not only found in structural proteins but also play important roles in various intracellular regulatory processes as well as membrane fusion. Due to their biological importance and striking appearance, the sequence-structure relationship of helical coils has been extensively studied. Current knowledge gained from systematic studies of the folding and oligomerization of individual amino acids in natural proteins and synthetic peptides has facilitated the de novo design of many different coiled-coil peptides that are widely used in the development of self-assembled, bioactive materials responsive to sequence.

Fig 1. Coiled coils and coiled coil-hybrids for drug delivery and therapeutics. (Utterström J, et al., 2021)

Services

Currently, coiled-coil hybrids and nanocomposites are produced primarily through the engineering of fusion proteins or by combining them with synthetic polymers, proteins, carbohydrates, lipids, and inorganic nanoparticles, using physical interactions or chemical conjugation. As a leading service provider of protein engineering, Creative BioMart has developed a large number of coiled coil peptides with various preferences and oligomeric affinities, and discovered abundant natural coiled coil sequences.

Through careful application of rational design, our scientists have developed a variety of strategies to modify sequences at structurally permissible sites to tailor helical coils for specific applications. We offer services to combine coiled coils with other molecules and nanostructures such as synthetic polymers, biopolymers, lipids and inorganic nanoparticles to generate hybrid and composite materials. We offer the following engineered coiled coil peptides for you to choose from:

• Coiled-coil design in liposomal drug delivery systems
• Lipid coil design for assembly of virus-like particles
• Coiled-coil nanoparticle design
• Coiled-coil nanocarrier design
• Coiled polymer-hybrid design
• Coiled-coil-based hydrogel design
• Design of inorganic nanoparticle hybrid with coiled-coil
• Coiled-coil design combined with cell penetrating peptides
• Coiled-coil design for improved aiming

Creative BioMart is committed to developing coiled-coil-based materials for global pharmaceuticals to manufacture innovative drug delivery systems and develop new therapeutic strategies. We will work with you to develop the most appropriate strategy and provide the most meaningful data for your research for accelerating the research of life sciences. If you are interested in our services, please do not hesitate to contact us for more information.

Reference

1. Utterström J, Naeimipour S, Selegård R, et al.. (2021) Coiled coil-based therapeutics and drug delivery systems. Advanced Drug Delivery Reviews. 170: 26-43.

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