Creative BioMart is a well-known expert who uses various protein domains as non-antibody scaffolds to produce synthetic binding proteins that have the ability to bind to molecules. With years of experience, we successfully designed artificial avimers proteins based on non-antibody scaffolds to precisely meet customer requirements.

Introduction of Avimers Protein

Avimers is an artificial protein with multiple binding sites that can specifically bind to antigens. Avimer proteins are composed of two or more peptide sequences with the length of about 30–35aa, which are connected to each other by linker peptides. The main origin of individual peptide sequences is the A domain of various membrane receptors. Domains of this family bind over 100 different known targets(small molecules, proteins and viruses), by connecting multiple independent binding domains will generate affinity and improve affinity and specificity. Avimers has become a powerful tool for protein engineering design due to its small size, high stability, strong binding affinity to target molecules, specificity, and high resistance to thermal denaturation and enzymatic degradation. It is widely used for early detection of tissue imaging, treatment and carcinogenesis research.

Fig 1. Overview of avimer technology. (Silverman J, et al., 2005)

Services

Most therapeutic antibodies have some limitations, including low half-life, large size, weak stability to thermal and enzymatic degradation, and inappropriate reactions to target molecules. Avimers uses its modular nature and consistent physical properties to overcome the limitations of antibodies and other immunoglobulin-based therapeutic proteins. As a leading service provider of protein engineering, Creative BioMart provides design and synthesis services for avimers binding proteins, providing a strong background for the production of various non-molecular drugs. It is widely used in clinical treatment of diseases, such as Crohn's disease, itself immunity and various cancers. In addition, we can generate high-affinity avimers phage display library with 100% precise mutations and more than 1010 diversity, which is suitable for sorting and separating high-affinity protein or peptide targets.

The latest advances in combinatorial protein engineering make non-antibody scaffolds potentially replace most of the complete antibody-related properties, and can be transformed into biological products with similar drug properties. Avimer domains are naturally present in membrane polypeptides and mediates a variety of protein-protein interactions. The avimers proteins design platform developed by Creative BioMart has been well received by customers worldwide. The Avimers protein we designed can be used to increase the cartilage retention time of protein therapeutics. We use modern molecular technology to detect avimers proteins (as a biomarker in tissue imaging) in the early stages of cancer, which play an important role in treatment and disease process research.

Based on the protein engineering platform, we have successfully designed a variety of platforms for different applications to produce special proteins. We will work with you to develop the most appropriate strategy and provide the most meaningful data for your research for accelerating the research of life sciences. If you are interested in our services, please do not hesitate to contact us for more information.

References

1. Silverman J, Liu Q, et al.. (2005) Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains. Nat Biotechnol. 23(12): 1556-1561.
2. Jeong KJ, Mabry R, Georgiou G.(2005)  Avimers hold their own. Nat Biotechnol. 23(12): 1493-1494.

• Immunoglobulin-Like β-Sandwich Protein Design
• Repeat Protein Design
• Single Loop Protein Design
• Zinc Finger Protein Design
• α-Helical Scaffolds Protein Design
• β-Barrel Protein Design
• β-Sheet Surface Protein Design