Tissue engineering stimulates tissue repair by combining material design and engineering with cell therapy. Biomaterials can provide physical support for engineered tissues to guide cells. With its advanced protein engineering platform established over the years, Creative BioMart is using the tunable properties of protein-engineered biomaterials to independently tailor a range of biomaterial properties, creating an attractive alternative to synthetic polymer scaffolds or harvested natural scaffolds. Our scientists are committed to providing fully customized biomaterials for tissue regeneration solutions to customers around the world.

Introduction of Tissue Regeneration Biomaterials

Body tissues have highly organized structures and unique compositions that help provide mechanical and transport support to regulate biological and cellular functions. Due to tissue damage, disease, failure or aging, there is a need for naturally biodegradable and biocompatible materials that can mimic actual tissue structure and structural tissue. Autografts, allografts, have traditionally been used to treat injured tissue or organs, but have been limited by the resulting donor site morbidity and loss of organ function. Developments in tissue engineering and regenerative medicine provide new cytocompatible and nontoxic biomaterials to address this challenge. In addition, protein engineering uses protein-based biomaterials for the fabrication of next-generation scaffolds that include adequate mechanical and structural support and enable control of cell attachment, migration, proliferation, and differentiation. The researchers also used these biomaterials as bioabsorbable temporary implants, allowing the body to heal on its own at the same rate as the implants degrade.

Fig 1. Illustration of salient features of biomaterials required for Tissue engineering. (Sharma K, et al., 2019)

Solutions

The modularity, tunability, and sequence specificity of protein-engineered biomaterials make them attractive candidates for use as substrates for various tissue engineering applications. Creative BioMart has successfully utilized rationally designed protein engineering strategies to develop a variety of protein-based tissue regeneration biomaterials, including those with adequate mechanical and structural support, controlled cell attachment, migration, proliferation and differentiation, and bioabsorbable properties. In addition, we also combine them with bioactive molecules to enhance in vitro or in vivo functions to improve their properties. In order to provide customized high-quality tissue regeneration biomaterials to global customers, we have rationally designed the following proteins to provide solutions for tissue regeneration, including but not limited to:

• Collagen based tissue regeneration biomaterials
  Collagen is easily modified and processed, and its abundance, non-antigenicity, biodegradability, biocompatibility, and plasticity make it a promising biopolymer. Our designed collagen scaffolds have been widely used in soft tissue repair, dermal tissue engineering and bone repair.
• Fibronectin based tissue regeneration biomaterials
  Fibronectin plays an important role in the structural support and signaling of cell survival, migration, shrinkage, differentiation, and growth factor signaling. Our protein engineers use fibronectin or protein domains to functionalize tissue engineering scaffolds.
• Elastin based tissue regeneration biomaterials
  Elastin is part of the core structure that supports cell adhesion and growth. Our designed elastin scaffolds have been widely used in the production of vascular grafts, bone repair and drug delivery.
• Fibrin based tissue regeneration biomaterials
  Fibrin is a specialized extracellular matrix protein with potential applications in tissue engineering. Our protein engineers use it in scaffold form for tissue engineering for a range of tissue needs such as cartilage repair, vascular grafts and bone regeneration.
• Recombinant protein based tissue regeneration biomaterials
  Our protein engineers efficiently clone and express proteins in different recombinant systems. These proteins show great potential in the synthesis of biopolymers for tissue engineering and regenerative medicine.

Advantages of Protein-based Tissue Regeneration Biomaterials

• Combining cell adhesion and migration, mechanical properties, and antimicrobial factors to form multifunctional biomaterial systems.
• Efficiently mimics the highly organized structure of tissues and organs to direct adequate amounts of nutrient transfer, oxygen transport, and other biological functions.
• They have high performance, mechanical efficiency, biocompatibility and degradability.
• Helping restore and repair dysfunctional tissues and organs, increasing life expectancy and improving quality of life.

Creative BioMart has in-depth knowledge and experience of the tools and processes involved in biomaterials development, and provides professional protein-based tissue regeneration materials production solutions for the customers. Whether your tissue regeneration materials are in the discovery stages, or are planning engineered tissue regeneration materials production, please contact us to discuss further details to ensure your next success.

References

1. Gomes S, Leonor I B, Mano J F, et al.. (2012) Natural and genetically engineered proteins for tissue engineering[J]. Progress in polymer science. 37(1): 1-17.
2. Sharma K, Mujawar M A, Kaushik A. (2019) State-of-art functional biomaterials for tissue engineering[J]. Frontiers in Materials. 172.

• Biomaterials for Adhesives
• Biomaterials for Wound Healing